| 摘要: |
| 目的：研制一种新型、口径可调节的免缝合人造主动脉弓移植物并应用于动物实验研究。方法：移植物用镍钛形状记忆合金（NiTiNOL）丝以“Z”形波纹形状串联构成主动脉弓主体骨架，NiTiNOL管镂空支架构成主动脉弓上分支血管骨架，用膨体聚四氟乙烯（ePTFE）薄膜包覆移植物骨架。血管吻合方式为直接腔外结扎，无需手工缝合。应用该新型移植物施行猪主动脉弓手术并对其外科实用性和吻合可靠性进行评价。结果：实验动物8只，其中6只完成主动脉弓手术。平均旁路循环时间10 min，除1只动物因移植物选择不当造成吻合口渗血量较多外，其余5只动物术后8 h内的渗血量均不足100 ml。结论：新型主动脉弓移植物具备较强的外科实用性和良好的吻合可靠性，具有较好的临床应用前景。 |
| 关键词: 主动脉弓 缝合 移植物 动物实验 |
| DOI：10.3724/SP.J.1008.2007.01339 |
| 投稿时间：2007-04-27 |
| 基金项目:上海市卫生局医学领军人才计划(LJ06101). |
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| A novel regulable sutureless aortic arch prosthesis: an experimental study |
| HAN Qing-qi, XU Zhi-yun*，ZHANG Bao-ren, HUANG Sheng-dong，HAN Lin, LU Fang-lin, SUN Zhi-gang, ZHOU Dong, LIU Hong-cheng |
| (Department of Cardiothoracic Surgery，Changhai Hospital，Second Military Medical University，Shanghai 200433，China) |
| Abstract: |
| Objective：To develop a novel regulable sutureless aortic arch prosthesis and to apply it in an animal experimental study. Methods: The arch skeleton of the prosthesis was made of tandem Z-shape NiTiNOL wire; the branch skeleton was made of laser-cut NiTiNOL tube; and the whole skeleton was coated with thin ePTFE film. The blood vessel was anastomosed by direct ligature, needing no manual suturing.The prosthesis was applied in swine aortic arch operations under the bypass condition. The practicality for surgery and the feasibility of anastomosis of the prosthesis were assessed. Results: Aortic arch operations were successfully performed in 6 of the 8 experimental animals. The prostheses were easy to use, and the mean bypass time was only 10 min. The blood loss of the anastomoses was less than 100 ml within 8 h postoperatively in 5 animals; one had more blood loss due to prosthesis mismatch.Conclusion: The novel regulable sutureless aortic arch prosthesis has satisfactory practicality for surgery and reliable anastomosis, making it promising in future clinical application. |
| Key words: aortic arch sutures prosthesis animal experimentation |
