| 摘要: |
| 目的：用FAIR序列探讨肺组织膨胀程度对肺灌注的影响，即在不同呼吸相时肺灌注的变化情况。方法：应用GE 1.5T磁共振成像系统，用FAIR序列对10例健康志愿者分别在呼气末和吸气末屏气时进行冠状面扫描。分析在不同呼吸相时反转脉冲标记前/后双肺信号强度变化率（ΔSI%）、肺血流量（PBF）的变化及扫描层面肺面积（Area）的变化情况。结果： (1)不同呼吸相时ΔSI%之间有明显的统计学差异（右肺P=0.021 5，左肺P=0.008 4），呼气末的ΔSI%明显高于吸气末。(2)不同呼吸相时双肺PBF间均有统计学差异（右肺P=8.92×10-5，左肺P=0.000 2），呼气末的PBF明显高于吸气末。(3)不同呼吸相扫描层面的Area间也有明显的统计学差异（右肺P=2.94×10-5，左肺P=0.000 5），吸气末面积明显大于呼气末面积。结论：不同呼吸相时肺灌注间存在差异，在呼气时肺灌注明显高于吸气时，这与呼气时肺容积缩小、血管密度增加有关。 |
| 关键词: 肺 灌注，局部 动脉自旋标记 磁共振成像 肺膨胀 |
| DOI：10.3724/SP.J.1008.2007.01197 |
| 投稿时间：2007-07-19 |
| 基金项目:长征医院“三重三优”优秀学科带头人基金（20060109）. |
|
| Influence of lung inflation on arterial spin labeling signal in MR perfusion imaging of human lungs |
| FAN Li,LIU Shi-yuan*,XIAO Xiang-sheng,XU Xue-yuan |
| (Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| Objective：To investigate the influence of lung inflation on MR perfusion imaging of human lung using an arterial spin labeling sequence called flow sensitive alternating inversion recovery (FAIR). Methods: Coronal perfusionweighted images were obtained at different respiratory phases from 10 healthy volunteers on a 1.5T whole body scanner (GE medical system) using FAIR sequence. The changes of tagging efficiency of pulmonary parenchyma (ΔSI %), pulmonary blood flow and area of the scanning slice of different respiratory phases were analyzed. Results: (1) Significant difference was found in ΔSI% between different respiratory phases（right lung P=0.021 5，left lung P=0.008 4）, with that at end expiration greater than that at end inspiration. (2) Significant difference was also found in pulmonary blood flow at different respiratory phases (right lung P=8.92×10-5，left lung P=0.000 2), with that at end expiration higher than that at end inspiration. (3) The areas of the scanning slice were also significantly different at different respiratory phases (right lung P=2.94×10-5，left lung P=0.000 5), with that at end inspiration larger than that at end expiration. Conclusion: Pulmonary blood flow during expiration is higher than that during inspiration, which might be due to the decreased lung volume and increased vascular density during expiration. |
| Key words: lung perfusion,regional arterial spin labeling magnetic resonance imaging lung inflation |
