| 摘要: |
| MicroRNAs (miRNAs)是广泛存在的非编码小RNA，通过干预mRNA翻译的方式负向调控基因的表达，具有肿瘤抑制基因和癌基因的双重作用，其在肿瘤发生中所发挥的作用补充、丰富了肿瘤的发生机制。肝癌严重威胁人类健康，但其发病机制尚未完全清楚。miRNAs对肝癌的发生、分化及其治疗策略均有影响，本文就近年来miRNA与肝癌诊治的相关研究作一综述。 |
| 关键词: 微小RNA 肿瘤抑制基因 癌基因 肝肿瘤 |
| DOI：10.3724/SP.J.1008.2008.00561 |
| 投稿时间：2008-01-23修订日期：2008-04-01 |
| 基金项目: |
|
| MicroRNAs and liver cancer: recent progress |
| YE Ping,YU Feng-hai* |
| (Department of Gastroenterology,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China) |
| Abstract: |
| MicroRNA (miRNA) is a small non-coding RNA that contains 21 to 23 nucleotides and can down-regulate gene expression by translational repression.Recent studies found that some miRNAs might function both as oncogenes and tumor suppressors;its role in the tumorigenesis may complement and enrich the mechanisms of tumorigenesis.Liver cancer is a great threat to human health,whose pathogenesis is still not completely understood.MiRNAs can influence the tumorigenesis,differentiation and treatment of liver cancer.Here we summarizes the related progression in research of miRNA and liver cancer. |
| Key words: microRNA suppressor tumor genes oncogenes liver neoplasms |
