| 摘要: |
| 目的:应用滴入分散法制备眼用氟尿嘧啶-壳聚糖纳米粒(5-Fu-CS-NP),并对其体外释放进行考察。方法:将壳聚糖、聚丙烯酸与氟尿嘧啶通过滴入分散法形成聚电解质络合物制备5-Fu-CS-NP。考察纳米粒粒径、包封率、载药量以及体外释药特性。 结果和结论:5-Fu-CS-NP平均粒径为(144.6±3.1) nm,包封率为84.5%,载药量为3.91%。5-Fu-CS-NP有较好的缓释作用,能在3～7 d内持续释放药物。在pH值7.2～7.4的生理范围内,释放速率变化不大。 |
| 关键词: 氟尿嘧啶 壳聚糖 聚丙烯酸 纳米技术 后囊膜混浊 |
| DOI：10.3724/SP.J.1008.2008.00 |
| 投稿时间：2008-02-01修订日期：2008-05-19 |
| 基金项目:上海市科委纳米专项基金(0452nm015);全军“十一五”医药卫生科研基金(06MA177). |
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| Preparation and in vitro evaluation of fluorouracil nanoparticles for ophthalmologic usage |
| HUANG Xiao,WEI Rui-li*,weiruili |
| (Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| Objective:To prepare fluorouracil-loaded chitosan nanoparticle (5-Fu-CS-NP) for ophthalmologic usage and evaluate its releasing characteristics in vitro. Methods: 5-Fu-CS-NP was prepared with 5-Fu, polyacrylic acid and chitosan using dispersion method. The mean size, entrapment efficiency (EE%), drug loading (DL%) and the in vitro releasing characteristics of 5-Fu-CS-NP were investigated.Results and conclusion: The mean size of 5-Fu-CS-NP was (144.6±3.1) nm, the EE% was 84.5% and the DL% was 3.91%. 5-Fu-CS-NP had a satisfactory sustained-releasing effect and the releasing could last for 3-7 days, and the release behavior was not greatly changed within a pH value of 7.2-7.4. |
| Key words: fluorouracil chitosan polyacrylic acid nanotechnology posterior capsule opacification |
