| 摘要: |
| 目的:观察终末期肾病患者血清成纤维细胞生长因子23(FGF-23)水平及其与钙磷代谢的关系。 方法: 采集50例血透患者、24例腹透患者及20名健康对照者的静脉血,离心取血清,采用ELISA法测定FGF-23水平,同时检测水平在1,25-二羟维生素D\[1,25-(OH)2VitD\]、全段甲状旁腺激素(iPTH)、血清肌酐(Scr)、钙(Ca)、磷(P)等水平。结果:FGF-23水平在血透组患者\[(88.51±35.01) ng/L\]、腹透组患者\[(87.85±33.65) ng/L\]均明显高于健康人群\[(11.76±3.63) ng/L\],但血透组和腹透组无统计学差异。而血透组、腹透组患者血清1,25-(OH)2VitD水平均明显低于健康对照组(P<0.01),且血透组明显低于腹透组(P<0.01)。Pearson相关性分析结果显示血清FGF-23与血清肌酐、iPTH、磷、透析时间呈正相关(P<0.01),与1,25-(OH)2VitD负相关(P<0.01)。结论:终末期肾病患者FGF-23水平明显升高,1,25-(OH)2VitD明显降低。FGF-23水平变化与血清肌酐、iPTH、磷、透析时间、1,25-(OH)2VitD等多种因素有关。 |
| 关键词: 成纤维细胞生长因子 终末期肾病 磷 1,25-二羟维生素D |
| DOI：10.3724/SP.J.1008.2008.01184 |
| 投稿时间：2008-04-09修订日期：2008-06-20 |
| 基金项目: |
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| Changes of serum fibroblast growth factor 23 in patients with end stage renal disease and its clinical significance |
| ZHANG Jun-li*, HUAN Hong-di, ZHANG Jing-hong, YANG Jun, LU Bei-li, YANG Huang |
| (Department of Nephrology, No. 85 Hospital of PLA, Shanghai 200052,China) |
| Abstract: |
| Objective:To observe the serum level of fibroblast growth factor-23(FGF-23) in patients with end stage renal disease (ESRD) and study its association with phosphorus and vitamin D metabolism.Methods: Serum FGF-23 level was determined by enzyme-linked immunosorbent assay (ELISA) in ESRD patients undergoing haemodialysis (HD, n=50) and peritoneal dialysis (PD, n=24) and in twenty healthy controls (control group,n=20).Serum level of 1，25-(OH) 2VitD was measured by enzyme immunoassay(EIA).Serum intact parathyroid hormone (PTH), creatinine, and calcium and phosphorus were also measured.Results: Serum FGF-23 was obviously higher in HD group（\[88.51±35.01\] ng/L vs \[11.76±3.63\] ng/L）and PD group（\[87.85±33.65\] ng/L vs \[11.76±3.63\] ng/L）than in control group. Moreover, the serum level of 1，25-（OH）2VitD was lower in HD and PD groups than in control group (\[19.82±4.99\] pmol/L vs \[48.37±3.47\] pmol/L; \[24.31±7.11\] pmol/L vs \[48.37±3.47\] pmol/L ), and the level of 1，25-（OH）2VitD was much lower in HD group than in PD group. Pearson relativity analysis showed that serum FGF-23 level was positively correlated with serum creatinine, phosphorus, intact PTH and duration of dialysis(P<0.01); and was negatively correlated with 1，25-（OH）2VitD(P<0.01). Conclusion: Serum FGF-23 is greatly up-regulated in patients with ESRD, and the level of serum 1，25-（OH）2VitD is down-regulated. The changes of FGF-23 is associated with serum creatinine, phosphorus, intact PTH and 1，25-（OH）2VitD. |
| Key words: fibroblast growth factors end stage renal disease phophorus 1,25-dihydroxy vitamin D |
