| 摘要: |
| 肿瘤微环境与肿瘤发生发展密切相关。最近的研究证实，肿瘤形成可能是干细胞分化异常导致。而微环境是干细胞稳态调节的关键，干细胞微环境的失调在肿瘤发生中扮演了重要角色。而在肿瘤发展过程中，适宜的微环境将促进肿瘤快速增殖，改变这些特异的微环境可以抑制肿瘤的恶性表型。同时，在肿瘤迁移过程中，微环境也起到了重要作用。这些机制的研究有助于加深对肿瘤的认识，为肿瘤的预防和治疗提供新的理论基础。 |
| 关键词: 微环境 肿瘤 干细胞 细胞增殖 |
| DOI：10.3724/SP.J.1008.2008.01239 |
| 投稿时间：2008-04-29修订日期：2008-06-30 |
| 基金项目:国家自然科学基金(30471994)；上海市科委浦江人才计划项目(045407047)；上海市教育委员会“曙光计划”项目(99SG24). |
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| The effect of tissue microenvironment on the initiation and development of cancer |
| SUN Kai， WEI Li-xin*，WU Meng-chao |
| (Tumor Immunology and Gene Therapy Center,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China) |
| Abstract: |
| Toumor microenvironment is closely related to the development and progression of tumors.Recently, researchers suggest that abnormal differentiation of stem cells might lead to the initiation of cancer.Microenvironment is the key to homeostatic regulation of stem cells.Disregulation of microenvironment plays an important role in the carcinogenesis.And during the development of tumor,a suitable microenvironment can promote the rapid proliferation of tumor.Changing the specific microenvironment can suppress the tumorigenic phenotype of aggressive cancer.Meanwhile,microenvironment also plays an essential role in cancer metastasis.Understanding of these underlying mechanisms will enhance our knowledge of cancer and will provide a novel basis for prevention and treatment of cancer.. |
| Key words: microenvironment neoplasms stem cells cell proliferation |
