| 摘要: |
| 随着耐药致病真菌的临床检出率不断攀升,其死亡机制的探讨也成为了热点。致病真菌的凋亡是由许多信号通路、调节因子和效应物质组成的复杂网络。致病真菌的凋亡与真菌的自体吞噬、线粒体凋亡通路、内源性和外源性因素的变化等密切相关。凋亡通路作为抗真菌药物研究的新靶点,其临床意义十分重大。因此,本文对致病真菌凋亡通路做一综述。 |
| 关键词: 致病真菌 细胞凋亡 信号通路 |
| DOI：10.3724/SP.J.1008.2008.01390 |
| 投稿时间：2008-04-30修订日期：2008-09-26 |
| 基金项目:国家自然科学基金(30630071,30870105). |
|
| Apoptotic mechanism of Pathogenic fungi：recent progress |
| DAI Bao-di2,CAO Ying-ying1,XU Yong-gang1,GAO Ping-hui1,WANG Yan1,JIANG Yuan-ying1，2* |
| (1.Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China; 2.Department of Pharmacology,Shenyang Pharmaceutical University,Shenyang 010016) |
| Abstract: |
| Apoptotic mechanism of Pathogenic fungi has become a focus of study due to the worsening situation of clinical drug resistance in fungi.Apoptosis of Pathogenic fungi is a complicated network involving many pathways,regulators and effectors.Besides,it is closely related to the autophagy,mitochondrial apoptotic pathways,and changes of endogenous and exogenous factors.As a new target of antifungal agent,apoptotic pathways are of great clinical importance.This paper reviews the apoptotic pathways of Pathogenic fungi. |
| Key words: Pathogenic fungi apoptosis signal pathways |
