| 摘要: |
| 目的:研究杜仲籽总苷的抗炎、镇痛作用。方法:采用二甲苯所致小鼠耳肿胀和大鼠角叉菜胶足肿胀方法，研究杜仲籽总苷的抗炎作用；采用热板法、醋酸扭体法、光照甩尾法，研究杜仲籽总苷的镇痛作用。结果:杜仲籽总苷的110、220 mg/kg剂量都能明显减少二甲苯所致小鼠耳肿胀的体积，杜仲籽总苷的55、110、220 mg/kg剂量在给药后4 h左右明显减少大鼠角叉菜胶足肿胀率；杜仲籽总苷的220 mg/kg剂量能显著提高热板和光电引起小鼠的痛阈值，杜仲籽总苷的110、220 mg/kg剂量能显著地减少醋酸引起的扭体次数。结论:杜仲籽总苷具有较强的抗炎、镇痛作用。 |
| 关键词: 杜仲籽总苷 抗炎 镇痛 |
| DOI：10.3724/SP.J.1008.2009.0413 |
| 投稿时间：2008-09-02修订日期：2009-02-19 |
| 基金项目:国家科技部支撑计划(2006BAI06A19-09) . |
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| Anti-inflammatory and analgesic activity of Eucommiae ulmoides seed total glycoside |
| SONG Lin-qi1， DU Xian-jie1，LIN Fei2，XIE Ren-ming1， SUN Wen-ji1 * |
| (1.Key Biomedical Laboratory of Shaanxi Province, Northwest University, Xi’an 710019, China; 2.College of Traditional Chinese Medicine of Shaanxi Province, Xianyang 712046) |
| Abstract: |
| Objective:To investigate the anti-inflammatory and analgesic activity of Eucommiae ulmoides seed total glycoside(EUG). Methods: Dimethyl benzene(DB)-induced mouse ear edema model and carrageein-induced rat paw edema model were employed for the anti-inflammatory activity experiment. The experiment for analgesic activity was done using hot plate test, photoelectricity-induced test and acetic acid-induced writhing method. Results: EUG at 110,220 mg/kg showed an obvious inhibitory effect against DB-induced mouse ear edema volume, and at 55， 110, 220 mg/kg it showed an obvious analgesic effect against carrageein-induced rat paw edema rate 4 hours after oral administration. At 220 mg/kg EUG notably raised the pain threshold in the mice stimulated by hot plate and photoelectricity. At 110,220 mg/kg EUG greatly reduced the number of acid-induced writhing. Conclusion: The result suggests that EUG has potential anti-inflammatory and analgesic activity. |
| Key words: Eucommiae ulmoides seed total glycoside anti-inflammatory analgesic |
