| 摘要: |
| 电压门控性钾通道维持神经元静息膜电位，参与细胞兴奋性的改变。在三叉神经痛发病过程中，三叉神经节神经元作为初级感觉神经元，在痛觉的传导和传递过程中起重要作用。电压门控性钾通道的多种类型在三叉神经节神经元中均有表达，激活时产生不同类型的钾电流。电压门控性钾通道功能的改变，及其与多种神经递质、炎性介质和受体间的相互作用，在三叉神经痛的发病过程中起到了重要作用。 |
| 关键词: 电压门控钾通道 三叉神经痛 三叉神经节 背根神经节 受体 |
| DOI：10.3724/SP.J.1008.2009.0432 |
| 投稿时间：2008-11-20修订日期：2008-12-17 |
| 基金项目:上海市科学技术委员会基金(08JC1405400). |
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| Voltage-gated potassium channels and trigeminal neuralgia |
| LI Na1, MA Bei2*, DENG Xiao-ming1* |
| (1.Department of Anaesthiology, Changhai Hospital, Second Military Medical University, Shanghai 200433,China;2.Department of Physiology, College of Basic Medical Sciences,Second Military Medical University, Shanghai 200433) |
| Abstract: |
| Voltage-gated potassium channels regulate cell membrane potential and excitability in neurons. Trigeminal ganglion as a primary sensory neuron plays an important role in the pain transduction and transmission of trigeminal neuralgia. Trigeminal ganglion neurons express many subtypes of voltage-gated potassium channels and they can evoke different type of K+ current when activated. The alteration of voltage-gated potassium channels and their interaction with neurotransmitters, inflammatory cytokines and receptors play important roles in the development of trigeminal neuralgia. |
| Key words: voltage-gated potassium channels trigeminal neuralgia trigeminal ganglion dorgalroot ganglia receptors |
