| 摘要: |
| 叉头样转录因子(FOXP3)是脊椎动物叉头样转录因子家族中的一员,通过调控Treg细胞的发育、分化和成熟,发挥其免疫抑制作用。在肿瘤学的研究领域中,FOXP3＋Treg细胞在肿瘤免疫逃逸机制中发挥了相当重要的作用。本文就FOXP3在各类肿瘤中的表达、肿瘤免疫中的作用机制以及免疫治疗中的作用作一综述。 |
| 关键词: FOXP3 Treg细胞 肿瘤免疫 |
| DOI：10.3724/SP.J.1008.2009.01077 |
| 投稿时间：2008-11-21修订日期：2009-02-21 |
| 基金项目: |
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| Role of FOXP3 in tumor immunity |
| XUE Lei,XU Zhi-fei* |
| (Department of Cardiothoracic Surgery,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China) |
| Abstract: |
| FOXP3,a member of the forkhead/winged-helix family,exerts its immunosupression effect by regulating the development,differentiation and maturation of CD4+ CD25+ regulatory T cells (Treg).Treg plays an important role in immune escape mechanism in oncology research.This article reviews the expression of FOXP3 in various types of tumors and its role in tumor immunology and immunotherapy. |
| Key words: forkhead box protein 3 regulatory T cell tumor immunity |
