| 摘要: |
| 肿瘤干细胞(cancer stem cells,CSC)是存在于肿瘤组织中的一小群具有干细胞性质的瘤细胞,具有高度自我更新和不定向分化的潜能,是形成不同分化程度肿瘤细胞和肿瘤不断扩展的源泉。多发性骨髓瘤（multiple myeloma,MM）肿瘤干细胞的发现以及对其与侧群（side population,SP）细胞的关系和龛(niche)等的相关研究为MM的发病机制提供了新的解释。 |
| 关键词: 多发性骨髓瘤 肿瘤干细胞 记忆B淋巴细胞 侧群细胞 龛 |
| DOI：10.3724/SP.J.1008.2009.0953 |
| 投稿时间：2008-12-02修订日期：2009-06-11 |
| 基金项目: |
|
| Cancer stem cells of multiple myeloma:recent progress |
| YANG Xiao-qun,GE Hui-juan,YU Hong-yu* |
| (Department of Pathology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China) |
| Abstract: |
| Cancer stem cells (CSCs) are a small proportion of tumor cells with the property of stem cells in the tumor tissue; they are capable of self-renewal,multi-lineage differentiation and serve as the source of tumor cells and tumor tissues.The discovery of multiple myeloma CSCs and the study on its relationship with side population cells and niche provide a new interpretation on the pathogenesis of multiple myeloma. |
| Key words: multiple myeloma neoplastic stem cells memory B-lymphocytes side population niche |
