| 摘要: |
| 氧化应激涉及多种疾病的发生和发展以及人体的衰老过程。DJ-1/PARK7基因编码DJ-1蛋白,研究发现其具有多种生物学功能,包括细胞的恶性转化、雄性精子成熟与受精、促进细胞增殖及抵抗氧化应激等。近年来DJ-1抗氧化应激功能日益受到重视。研究层次包括体外实验、体内实验和临床研究。其机制主要包括自身构型改变、分子伴侣作用、保护线粒体功能、调控抗凋亡基因和抗氧化相关基因。对DJ-1进一步研究可能为氧化应激相关性疾病的预防和治疗提供新策略。 |
| 关键词: DJ-1/PARK7基因 氧化性应激 细胞凋亡 |
| DOI：10.3724/SP.J.1008.2012.088 |
| 投稿时间：2011-05-18修订日期：2011-06-25 |
| 基金项目: |
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| Protective effect of DJ-1 against oxidative stress: an advance |
| WANG Zhi-yong,TANG Ling-zhen,GAO Tian-wen* |
(Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China
*Corresponding author.) |
| Abstract: |
| Oxidative stress is implicated in the pathogenesis and progression of various diseases as well as in the natural aging process. DJ-1/PARK7 gene encodes DJ-1 protein, which participates in malignant transformation, sperm maturation and fertilization, cell proliferation promotion, and anti-oxidative stress. The anti-oxidative stress effect of DJ-1 has been drawing increasing attention in recent years. There have been related in vitro, in vivo and clinical studies. The main mechanisms of its anti-oxidation effects included modifying configuration, playing the role of molecular chaperones, protecting the mitochondrial function, and regulating anti-apoptosis genes and antioxidant-related genes. Further research on DJ-1 may provide a new strategy for the prevention and treatment of oxidative stress-related diseases. |
| Key words: DJ-1/PARK7 gene oxidative stress apoptosis |
