| 摘要: |
| 载脂蛋白A5是一种新发现的主要与高密度脂蛋白(HDL)相关的载脂蛋白,在临床上具有明显的降低三酰甘油作用,近期发现其可修饰HDL,促进胆固醇的逆转运,可通过多种机制影响AS进程,具有潜在的抗AS作用。本文针对载脂蛋白A5的研究及其对AS的预防及治疗作用作一综述。 |
| 关键词: 载脂蛋白A5 动脉粥样硬化 血脂代谢 |
| DOI：10.3724/SP.J.1008.2012.092 |
| 投稿时间：2011-06-25修订日期：2011-08-25 |
| 基金项目:国家自然科学基金(30971126/C140206),上海市浦江人才计划(PJ1408400),上海市教委科研重点项目(11ZZ33). |
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| Apolipoprotein A5 and atherosclerosis |
| ZHANG Zhi-jia,QU Shen* |
(Department of Endocrinology, The 10th People’s Hospital of Shanghai, Tongji University School of Medicine, Shanghai 200072, China
*Corresponding author.) |
| Abstract: |
| Apolipoprotein A5 (ApoA5) is a newly discovered apolipoprotein which is closely associated with high-density lipoprotein (HDL) remodeling. Clinically it demonstrates potent triglyceride reducing effect. Recent studies have found that ApoA5 can increase cholesteroal reverse transportation and HDL function by remodeling HDL, and it can also influence the progression of atherosclerosis in the different ways, showing a potential anti-atherosclerosis effect. Here we briefly review the characteristics of ApoA5 and its potential protective effect against atherosclerosis. |
| Key words: apolipoprotein A5 atherosclerosis metabolism of lipids |
