| 摘要: |
| 目的 分析酵母遗传相互作用的基因组尺度的总体性质。方法 用网络的图论方法, 计算酵母遗传相互作用网络的拓扑性质。结果 酵母全基因组的遗传相互作用中, 基因的相互作用个数服从幂律分布, 幂指数接近3。平均相互作用的基因为87, 约2/3的基因只需通过1个基因就有遗传相互作用, 约1/3只需通过2个基因就有遗传相互作用。遗传相互作用网络的平均聚集系数是0.047。结论 酵母的基因通常具有多种而不是单一的功能, 而且基因之间遗传相互作用高度密集。 |
| 关键词: 酵母菌 遗传相互作用 基因组尺度 拓扑学 |
| DOI：10.3724/SP.J.1008.2011.01009 |
| 投稿时间：2011-06-27修订日期：2011-08-22 |
| 基金项目: |
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| Topological properties of genetic interaction network in yeast |
| CUI You-yi1*,ZHANG Zhuo2 |
(1. Jilin Railway Vocational and Technology College, Jilin 132001, China
2. Department of Cardiovasology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| ObjectiveTo analyze the topological properties of genomic-wide genetic interaction network in yeast. MethodsThe topological properties of genomic-wide genetic interaction network in yeast were calculated by the graph theory. ResultsA power law fit the degree distribution well in the genomic-wide genetic interaction network in yeast, with the exponent approaching 3. The Node’s degree followed a wide-tail distribution, with the average degree being 87. Two thirds of the genes had genetic interaction via only one gene, and about one third of the genes had genetic interaction via only 2 genes. The average clustering coefficient was 0.047. ConclusionThe gene function in yeast is usually multiple and the functional interaction between genes is highly condensed. |
| Key words: yeasts genetic interaction genome-scale topology |
