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| 转化医学:从转化研究到靶向治疗与个体化医学 |
| 杨义力1,2 |
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(1. 第二军医大学长征医院转化医学中心，上海 200003
2. Cancer and Development Biology Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA) |
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| 摘要: |
| 生命科学在基因组学、干细胞和微电子技术等领域已取得了突破性进展，然而如何诊断、治疗包括癌症在内的许多重要疾病仍然是医学实践中亟待解决的难题。因此，“转化医学”这一新的概念应运而生，开展和加强“转化研究”已逐渐成为共识。值得注意的是，转化研究不仅包括采用各种新方法、新技术研究疾病的发生机制及诊断和治疗，也强调从临床实践中提出问题，研究和解决与疾病诊治有关的重要课题。转化医学的另一个重要内容是个体化治疗，即根据疾病在分子水平的改变而采用特异的靶向药物治疗。目前能进行个体化靶向治疗的案例仍屈指可数，但随着对许多疾病机制的深入了解，新的诊断技术和生物标记的发现，以及更多靶向药物的开发，个体化治疗有望在不久的将来，从特例成为临床实践中的常规。 |
| 关键词: 转化医学 转化研究 个体化医学 靶向治疗 |
| DOI：10.3724/SP.J.1008.2012.001277 |
| 投稿时间：2012-10-25修订日期：2012-11-28 |
| 基金项目: |
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| Translational medicine: from translational research to targeted therapy and personalized medicine |
| YANG Yi-li1,2 |
(1. Center for Translational Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2. Cancer and Development Biology Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA) |
| Abstract: |
| Despite of tremendous progresses made in the genomics, stem cell technology, and microelectronics, challenges remain for the diagnosis and treatment of many diseases including cancer. Thus the conception of “translational medicine” appeared and it is generally believed that translational researches should be intensified. Translational researches not only include the application of new methods and advanced technologies, but also emphasize the raise of problems from clinical practice and study and solve them for diagnosis and treatment. Another important aspect of translational medicine is personalized treatment of diseases, i.e., using targeted drugs against specific molecular changes in individual patient. Although there are only a handful of examples for targeted therapy, we believe that, with the deeper understanding of the mechanisms of more diseases, discovery of more biomarkers and diagnostic methods, and development of more targeted drugs, personalized therapy will become popular in clinic in the future. |
| Key words: translational medicine translational research personalized medicine targeted therapy |
