| 摘要: |
| 目前针对晚期胃癌的化疗方案不断涌现，但晚期胃癌患者预后仍然较差，分子靶向治疗是除化疗之外治疗晚期胃癌的又一重要方向。针对诸多影响胃癌发生发展的靶点如表皮生长因子受体、人类表皮生长因子受体2、血管内皮生长因子、血管内皮生长因子受体、环氧合酶2等，出现了各种靶向治疗药物，多项Ⅱ/Ⅲ期临床研究正在进行或已经完成。本文结合最新研究报道，对胃癌分子靶向治疗的最新进展作一综述。 |
| 关键词: 胃肿瘤 分子靶向治疗 表皮生长因子受体 血管内皮生长因子类 血管内皮生长因子受体 环氧合酶2 |
| DOI：10.3724/SP.J.1008.2014.00305 |
| 投稿时间：2013-08-05修订日期：2013-12-06 |
| 基金项目: |
|
| Molecular targeted therapy of gastric cancer：recent progress |
| WANG Zai-biao,MA Li-ye* |
(Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Despite chemotherapy regimens for advanced gastric cancer keep emerging, the patients still have poor prognosis. Molecular targeted therapy is another important direction for the treatment of advanced gastric cancer. Various drugs for molecular targeted therapy have been developed targeting epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER-2), vascular endothelial growth factor (VEGF) and its receptor (VEGFR), and cyclooxygenase-2 (COX-2); a number of Ⅱ/Ⅲ clinical trial have been completed or being conducted. The aim of this review is to summarize the recent progress on molecular targeted therapy for gastric cancer. |
| Key words: stomach neoplasms molecular targeted therapy epidermal growth factor receptor vascular endothelial growth factors vascular endothelial growth factor receptor cyclooxygenase-2 |
