| 摘要: |
| 妊娠期高血压疾病(hypertension disorder complicating pregnancy,HDCP)是妊娠期特有的疾病,发病时可导致多器官功能损害或功能衰竭,严重时可出现抽搐、昏迷甚至死亡。该病严重威胁母亲和胎儿健康,是导致孕产妇和围生儿病死的重要原因之一,其病因至今尚未阐明。近年来诸多研究发现HDCP发生时常常伴随某些激素水平的变化,如孕激素、人绒毛膜促性腺激素(HCG)、甲状腺激素、促肾上腺皮质激素释放激素(CRH)等。本文就HDCP孕妇体内上述4种常见激素的变化情况及其与HDCP的相关性进行综述,为HDCP的病因研究及预测提供新思路。 |
| 关键词: 妊娠期高血压疾病 先兆子痫 孕激素类 绒毛膜促性腺激素 甲状腺激素类 促肾上腺皮质激素释放激素 |
| DOI： |
| 投稿时间：2013-08-06修订日期：2013-12-05 |
| 基金项目:国家自然科学基金 |
|
| Endocrine hormones and hypertension disorder complicating pregnancy: a review |
| LIANG Yan1,2△,HAO Fan1△,XU Ming-juan1* |
(1. Department of Obstetrics and Gynecology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2. Department of Obstetrics and Gynecology, Qinghai Red Cross Hospital, Xining 810000, Qinghai, China
*Corresponding author.) |
| Abstract: |
| Hypertension disorder complicating pregnancy (HDCP) can be associated with multiple organ dysfunction or failure, even convulsions, coma and death in severe cases. HDCP poses a serious threat to maternal and fetal health, and is one of the important reasons for maternal and perinatal infant mortality. However, the etiology of HDCP remains largely unknown. Recently many studies have found HDCP is accompanied by changes of some hormones, including progesterone, human chorionic gonadotropin, thyroid hormone and corticotropin-releasing hormone. In this review we delineated the fluctuations of the above four common hormones in HDCP patients and their relation with HDCP, hoping to cast new sights for its etiology and prediction. |
| Key words: hypertension disorder complicating pregnancy pre-eclampsia progestins chorionic gonadotropin thyroid hormones corticotropin-releasing hormone |
