| 摘要: |
| 棘皮动物微管结合蛋白4(echinoderm microtubule associated protein-like 4，EML4)与间变淋巴瘤激酶(anaplastic lymphoma kinase，ALK)形成的融合基因被认为是非小细胞肺癌（NSCLC)新的分子靶点。该融合基因在年轻，不吸烟或少吸烟，腺癌的非小细胞肺癌患者中发生率较高。本综述重点阐述NSLCL中EML4-ALK的生物学特性，检测方法，临床特征和治疗。 |
| 关键词: 非小细胞肺癌；EML4-ALK 融合基因 |
| DOI：10.3724/SP.J.1008.2014.00898 |
| 投稿时间：2013-11-06修订日期：2014-07-01 |
| 基金项目: |
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| Reseach progress of EML4-ALK Fusion Gene in Non-small Cell Lung Cancer |
| 赵静,zhengjianming,yuyongwei |
| (Department of Pathology, Affiliated Changhai Hospital of Second Military Medical University, Shanghai) |
| Abstract: |
| The fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase(ALK) has recently been identified as a new molecular target of non-small cell lung cancers(NSCLC).The fusion gene has higher morbidity in NSCLC patients who are young , never or light smoking history and adenocarcinomas.This review emphasizes the biological,detection method,clinical characteristics and the therapeutic application of EML4-ALK in NSCLC. |
| Key words: Non-small cell lung cancer EML4-ALK fusion oncogene |
