| 摘要: |
| 姜黄素是从姜科植物根茎中提取的相对分子质量较小的多酚类物质,具有抗肿瘤、抗炎、抗病毒、抗氧化等多种药理作用,随着现代医学发展,姜黄素抗肿瘤药理作用的分子机制被不断认识.肿瘤的形成和发展是一个多阶段的过程,药物干预可作用于其中的任何阶段,人类希望能找到安全、高效的肿瘤预防与治疗药物.食物来源的天然药物姜黄素因具备较低的毒副作用、较高的安全性和较高的依从性,可被各类人群尤其是中低风险人群长期服用,而备受关注.然而姜黄素的一些理化性质决定了其应用不尽理想,如何改善这些缺陷逐渐成为当前研究姜黄素的热点.该文就天然食物来源的预防肿瘤药物姜黄素应用新剂型进行综述. |
| 关键词: 姜黄素 抗肿瘤药 剂型 纳米技术 |
| DOI：10.3724/SP.J.1008.2015.00771 |
| 投稿时间：2014-12-04修订日期：2015-02-10 |
| 基金项目:国家自然科学基金(81271694). |
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| Research progress in new formulation of curcumin for anti-tumor |
| DONG Wei,LIU Hui* |
(Department of Hepatic Surgery (Ⅲ), Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
*Corresponding author) |
| Abstract: |
| Curcumin, a relatively low molecular weight polyphenol, is derived from the plant Curcuma longa, possessing anti-tumor, anti-inflammation, anti-virus, and anti-oxygenation effect. The anti-tumor effect of curcumin and its molecular mechanism are gradually recognized. The development and progression of tumor is multi-staged and drug intervention can be applied to any of these stages. We need drugs which can prevent and treat cancers safely and effectively. Natural medicine from food sources, such as curcumin, is suitable for all and for long-term use, especially in patients with low to moderate risk, owning to its less side effects, high safety and high patient compliance. However, the physical and chemical characters of curcumin make its usage undesirable, so to overcome these shortcomings has become a focus of research on curcumin. In this article we reviewed the new formulations of curcumin for anti-tumor usage. |
| Key words: curcumin antineoplastic agents dosage forms nanotechnology |
