| 摘要: |
| 水通道蛋白是细胞膜转运水分子的特异性通道蛋白，在维持机体水平衡中发挥重要作用。研究发现水通道蛋白广泛分布在人体各组织器官，其表达异常与一系列水平衡紊乱导致的疾病密切相关。近年来针对水通道蛋白的基础研究、水通道蛋白特异性抑制剂和水通道蛋白分子靶向治疗等取得了诸多进展，本文对此进行综述。 |
| 关键词: 水通道蛋白质类 抑制剂 分子靶向治疗 视神经脊髓炎 辐射损伤 |
| DOI：10.16781/j.0258-879x.2018.07.0775 |
| 投稿时间：2018-01-06修订日期：2018-05-07 |
| 基金项目:国家自然科学基金（31271264，81301054），上海市自然科学基金（13ZR1450600），上海市卫生局青年科研项目（2012Y142）. |
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| Advances in aquaporin inhibitors and molecular targeted therapy |
| HU Hao1,2,JIANG Hua1* |
(1. Department of Plastic Surgery, Changzheng Hospital, Navy Medical University(Second Military Medical University), Shanghai 200003, China;
2. Department of Dermatology, General Hospital of Armed Police Forces, Beijing 100600, China
*Corresponding author) |
| Abstract: |
| Aquaporins (AQPs) are the specific channel proteins located in cell membrane for transporting water, and they play an important role in maintaining the body's water balance. AQPs are widely distributed in human tissues and organs, and their abnormal expressions are closely related to a series of diseases caused by water balance disorders. In recent years, great advances have been made in molecular researches, specific inhibitors, and targeted therapies of AQPs. In this review, we summarized the recent research progresses. |
| Key words: aquaporins inhibitors molecular targeted therapy neuromyelitis radiation injuries |
