| 摘要: |
| 人类足细胞抗原的不断涌现使得膜性肾病相关研究驶入了快车道。这些抗原为膜性肾病的明确诊断和疗效监测提供了可靠的生物学标志物，也使个性化治疗成为可能。随着检测技术的不断进步，越来越多的靶抗原走进了人们的视野，这既加深了我们对相关疾病的认识，也给原有的诊断分类带来了巨大的冲击。本文通过详述各型靶抗原相关膜性肾病的特点，阐明了原有分类不再适应现在临床工作的原因，同时综述膜性肾病新的诊断分类，并展望基因检测用于疾病诊断的前景。 |
| 关键词: 膜性肾病 靶抗原 诊断分类 基因检测 |
| DOI：10.16781/j.CN31-2187/R.20210987 |
| 投稿时间：2021-09-28修订日期：2021-12-06 |
| 基金项目: |
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| New diagnostic classification of membranous nephropathy with target antigens as the core and highlighting related diseases |
| REN Wei-fu,BIAN Qi* |
(Department of Nephrology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| The discovery of human podocyte antigens has promoted the research on membranous nephropathy. These antigens provide reliable biomarkers for the diagnosis and therapeutic monitoring of membranous nephropathy, and make it possible for personalized treatment. With the advance of detecting techniques, increasing target antigens of membranous nephropathy have been found, which not only improves our understanding of the disease, but also brings significant impacts on the existing diagnostic classification. This review sheds light on the characteristics of membranous nephropathy associated with target antigens, clarifies the reasons why the original classification is no longer suitable for the current clinical practice, summarizes the new diagnostic classification, and looks into the prospect of gene detection in diagnosis. |
| Key words: membranous nephropathy target antigen diagnostic classification gene detection |
