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| 健康成年女性人群中体重指数、瘦素与代谢-炎症性衰老的相关性 |
| 赵莉1,陈艳娟2,彭锐1,吴伟晴1,雷焙焙2,刘冬舟2,洪小平2,何慧1*,陈永2* |
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(1. 深圳市人民医院（暨南大学第二临床医学院、南方科技大学第一附属医院）健康管理中心，深圳 518020;
2. 深圳市人民医院（暨南大学第二临床医学院、南方科技大学第一附属医院）风湿免疫科，深圳 518020
*通信作者) |
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| 摘要: |
| 目的 探究健康成年女性BMI、瘦素水平与代谢-炎症性衰老的相关性。方法 纳入2021年3－4月于深圳市人民医院健康管理中心进行健康体检的健康成年女性38人。收集血压、BMI及血生物化学检查结果，包括血清白蛋白、球蛋白、血糖、糖化血红蛋白（GHb)、总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、血尿酸、甲胎蛋白等。通过人脂肪因子磁珠面板检测试剂盒测定血浆瘦素及炎症因子TNF-α、γ干扰素水平。采用Pearson或Spearman相关分析探究年龄、BMI及瘦素水平与血压、BMI、血生物化学指标及炎症因子等的关系。结果 38名健康成年女性中育龄期（＜45岁且停经不超过12个月）22例、围绝经期及绝经期（≥45岁或停经12个月后）16例，（围）绝经期女性BMI及ALT、血糖、GHb、总胆固醇、甘油三酯、LDL-C、甲胎蛋白、瘦素、γ干扰素水平均高于育龄期女性（P均＜0.05）。随着年龄的增长，血清白蛋白水平呈下降趋势（r＝－0.339，P＜0.05），而GHb、BMI、总胆固醇、LDL-C、甲胎蛋白均逐渐升高（r＝0.364、r＝0.378、rs＝0.540、r＝0.559、r＝0.451，P均＜0.05）。BMI与收缩压、舒张压、血糖、血尿酸呈正相关（r＝0.395、0.461、0.350、0.395，P均＜0.05），与HDL-C呈负相关（r＝－0.472，P＝0.006）。血浆瘦素水平随着年龄的增长而升高（r＝0.390，P＜0.05），并与BMI、收缩压、总胆固醇、LDL-C、甘油三酯、血尿酸、ALT及TNF-α呈正相关（r＝0.378、r＝0.394、rs＝0.412、r＝0.355、rs＝0.567、r＝0.518、rs＝0.372、r＝0.347，P均＜0.05）。结论 在健康成年女性人群中，随着年龄增长、BMI增加，机体代谢、炎症水平发生变化；白蛋白、瘦素、甲胎蛋白及TNF-α等可作为临床评估衰老的潜在指标。 |
| 关键词: 衰老 瘦素 体重指数 脂质代谢 炎症 |
| DOI：10.16781/j.CN31-2187/R.20220123 |
| 投稿时间：2022-02-10修订日期：2022-04-15 |
| 基金项目:中国博士后科学基金项目(2021M701438) |
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| Correlation between body mass index, leptin and metabolic-inflammatory aging in healthy female adults |
| ZHAO Li1,CHEN Yan-juan2,PENG Rui1,WU Wei-qing1,LEI Bei-bei2,LIU Dong-zhou2,HONG Xiao-ping2,HE Hui1*,CHEN Yong2* |
(1. Health Management Center, Shenzhen People's Hospital (2nd Clinical Medical College of Jinan University, 1st Affiliated Hospital of Southern University of Science and Technology), Shenzhen 518020, Guangdong, China;
2. Department of Rheumatology and Immunology, Shenzhen People's Hospital (2nd Clinical Medical College of Jinan University, 1st Affiliated Hospital of Southern University of Science and Technology), Shenzhen 518020, Guangdong, China
*Corresponding authors) |
| Abstract: |
| ObjectiveTo explore the correlation between body mass index (BMI), leptin levels and metabolic-inflammatory aging in healthy female adults.MethodsThirty-eight healthy adult women who underwent physical examination in Health Management Center of Shenzhen People's Hospital from Mar. to Apr. 2021 were enrolled. Blood pressure, BMI, and blood biochemical test results, including serum albumin, globulin, blood glucose, glycosylated hemoglobin (GHb), total cholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid, and α-fetoprotein, were collected. Plasma leptin and inflammatory cytokines (tumor necrosis factor α[TNF-α] and interferon-γ) were determined by human adipokine magnetic bead panel kit. Pearson or Spearman correlation analysis was used to explore the relationships of age, BMI and leptin levels with blood pressure, BMI, blood biochemical indexes and inflammatory cytokines.ResultsTwenty-two of the 38 healthy adult women were of childbearing age (< 45 years old and less than 12 months of cessation of menstruation) and 16 were (peri)menopausal (≥45 years old or more than 12 months of cessation of menstruation). The BMI, ALT, blood glucose, GHb, total cholesterol, triglyceride, LDL-C, α-fetoprotein, leptin, and interferon-γ were significantly higher in the (peri)menopausal women than those in the childbearing women (all P < 0.05). With the increase of age, the level of serum albumin showed a downward trend (r＝－0.339, P < 0.05), while the levels of GHb, BMI, total cholesterol, LDL-C and α-fetoprotein were gradually increased (r＝0.364, r＝0.378, rs＝0.540, r＝0.559, r＝0.451, all P < 0.05). BMI was positively correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), blood glucose, and uric acid (r＝0.395, 0.461, 0.350, 0.395, all P < 0.05), and negatively correlated with HDL-C (r＝－0.472, P＝0.006). Plasma leptin level was increased with age (r＝0.390, P < 0.05), and was positively correlated with BMI, SBP, total cholesterol, LDL-C, triglyceride, uric acid, ALT, and TNF-α (r＝0.378, r＝0.394, rs＝0.412, r＝0.355, rs＝0.567, r＝0.518, rs＝0.372, r＝0.347, all P < 0.05).ConclusionIn healthy female adults, with the increase of age and BMI, the body metabolism and inflammatory levels change; albumin, leptin, α-fetoprotein and TNF-α can be used as potential indexes for clinical aging assessment. |
| Key words: aging leptin body mass index lipid metabolism inflammation |
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