| 摘要: |
| 羟基磷灰石/聚合物复合支架具有良好的机械性能、可降解性、成骨活性、缓释功能，将其作为细胞生长因子、细胞和药物载体用于骨修复成为骨组织工程的研究热点之一。本文主要就近年羟基磷灰石/聚合物复合复合支架负载细胞生长因子、细胞和药物在骨损伤或骨缺损治疗中的研究进展进行综述。 |
| 关键词: 羟基磷灰石 聚合物 复合支架 生长因子 载药支架 载细胞支架 骨修复 |
| DOI：10.16781/j.CN31-2187/R.20220809 |
| 投稿时间：2022-10-18修订日期：2023-09-22 |
| 基金项目:国家自然科学基金（81972076，82102605），国家重点研发计划（2020YFC2008404）. |
|
| Hydroxyapatite/polymer composite scaffolds in repairing bone defects: research progress |
| QI Junqiang1,CHEN Yu1,WANG Haotian1,YE Xiaojian2,XU Guohua1* |
(1. Spinal Minimally Invasive Center, Department of Orthopaedics, The Second Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200003, China;
2. Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
*Corresponding author) |
| Abstract: |
| Hydroxyapatite/polymer composite scaffolds have excellent mechanical properties, biodegradability, osteogenic activity, and sustained release function. With them as cell growth factors, cell and drug carriers for bone repair have become one of the research foci in bone tissue engineering. This article mainly reviews the research progress of hydroxyapatite/polymer composite scaffolds loaded with cell growth factors, cells, and drugs in the treatment of bone injuries or defects in recent years. |
| Key words: hydroxyapatites polymers composite scaffolds growth factors drug-loaded scaffolds cell-loaded scaffolds bone repair |
