| 摘要: |
| 我国是全球食管癌发病率和死亡率最高的国家之一，开展筛查和早期诊治是降低疾病负担的关键。上消化道内镜检查是诊断食管癌的金标准，但属于有创操作，难以实现人群广泛覆盖。采用相对简便、高效的筛查方式对筛查人群进行风险分层并对初筛高危者开展精准筛查，是更符合卫生经济学原则和我国国情的防控策略。本文主要介绍食管癌筛查中新路径与新方法的研究进展，包括食管癌风险预测模型，食管细胞学检测，以及血液、呼出气体和唾液标志物检测等，并展望其应用前景和未来发展趋势。 |
| 关键词: 食管肿瘤 鳞状细胞癌 筛查 早期诊断 体外诊断 |
| DOI：10.16781/j.CN31-2187/R.20220814 |
| 投稿时间：2022-09-19修订日期：2022-12-19 |
| 基金项目:上海市"科技创新行动计划"医学创新研究专项(21Y31900100). |
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| Precise screening of esophageal cancer: new approaches and methods |
| GAO Ye,TIAN Bo,WANG Luo-wei* |
(Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| China is one of the countries with the highest incidence and mortality of esophageal cancer worldwide. Screening and early detection are the keys to relieve the disease burden. Upper gastrointestinal endoscopy is currently the gold standard for the diagnosis of esophageal cancer, but its invasiveness limits the applicability in mass screening. Developing readily accessible and efficient methods for risk stratification and referring high-risk individuals for endoscopy are more cost-effective and suitable for the condition of China. We reviewed new approaches and methods in esophageal cancer screening, including risk prediction model, esophageal cytology, and biomarkers of blood, exhaled air and saliva, and proposed the research prospect. |
| Key words: esophageal neoplasms squamous cell carcinoma screening early diagnosis in vitro diagnostics |
