| 摘要: |
| 脑由于缺少常规的淋巴结构，一直被认为与外周淋巴系统完全隔绝。但是随着血管周围间隙、胶质淋巴系统及脑膜淋巴管的相继发现，人们开始认识到脑也有其独特的淋巴引流途径，且与外周淋巴系统相通。创伤性脑损伤作为制约神经外科整体救治水平的重要疾病之一，其伤后远期出现的记忆力下降、认知功能障碍等神经退行性表现一直未得到合理的解释。随着研究的不断深入，人们发现创伤性脑损伤后血管周围间隙、胶质淋巴系统及脑膜淋巴管都在一定程度上受到损伤，导致颅内淋巴系统功能下降，代谢产物在脑组织内大量堆积，从而影响神经功能导致出现神经退行性表现。 |
| 关键词: 颅内淋巴系统 血管周围间隙 胶质淋巴系统 脑膜淋巴管 创伤性脑损伤 慢性创伤性脑病 |
| DOI：10.16781/j.CN31-2187/R.20220946 |
| 投稿时间：2022-12-27修订日期：2023-04-25 |
| 基金项目: |
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| Intracranial lymphatic system and its relationship with traumatic brain injury: research progress |
| CHEN Kun,HOU Lijun* |
(Department of Neurosurgery, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
* Corresponding author) |
| Abstract: |
| The brain has been considered to be completely isolated from the peripheral lymphatic system due to lack of conventional lymphatic structures. However, with the discoveries of perivascular spaces, glymphatic system and meningeal lymphatic vessels, the brain has been recognized to have its own unique lymphatic drainage pathway connected with peripheral lymphatic system. Traumatic brain injury, as one of diseases influencing the treatment outcomes of neurosurgery, has not been reasonably explained for its long term neurodegenerative symptoms such as memory decline and cognitive dysfunction after injury. With the deepening of research, it has been found that the perivascular spaces, glymphatic system, and meningeal lymphatic vessels are all damaged to a certain extent after traumatic brain injury, leading to a decline in the function of intracranial lymphatic system and a large accumulation of metabolites in brain tissue, thereby affecting neurological function and resulting in neurodegenerative symptoms. |
| Key words: intracranial lymphatic system perivascular spaces glymphatic system meningeal lymphatic vessels traumatic brain injury chronic traumatic encephalopathy |
