| 摘要: |
| 低强度脉冲超声（LIPUS）是一种成本低、非侵袭性且安全性高的治疗方式，主要应用于骨骼肌肉系统疾病的治疗，尤其是骨折与骨不连的治疗。本文综述了LIPUS在多种骨骼肌肉及运动神经系统疾病中的治疗作用，并分析其可能的内在机制和潜在靶点，发现除了骨折与骨不连之外，LIPUS在治疗骨质疏松、肌肉损伤及运动神经系统疾病中同样具有临床应用前景。 |
| 关键词: 低强度脉冲超声 骨折 骨不连 骨质疏松 肌肉损伤 脊髓损伤 运动神经元病 |
| DOI：10.16781/j.CN31-2187/R.20220693 |
| 投稿时间：2022-08-27修订日期：2022-11-14 |
| 基金项目:上海市卫生健康委员会卫生行业临床研究专项（20194Y0232），军队高层次科技创新人才工程自主科研项目（2020QN06125），上海市曙光人才计划，海军军医大学（第二军医大学）第一附属医院基础医学研究专项（2023PY17），海军军医大学（第二军医大学）第一附属医院长虹人才计划． |
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| Biological effects of low-intensity pulsed ultrasound on musculoskeletal and motor nervous systems: research progress |
| LI Manping,CHEN Shaofeng,CHENG Yajun,BAI Yushu,LI Ming,WEI Xianzhao,ZHOU Xiaoyi* |
(Department of Spinal Surgery, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
* Corresponding author) |
| Abstract: |
| Low-intensity pulsed ultrasound (LIPUS) is a low-cost, non-invasive and safe treatment method mainly used for musculoskeletal diseases, especially for fractures and nonunion. This article reviews the therapeutic effects of LIPUS on various musculoskeletal and nervous system diseases and analyzes its mechanism and potential targets. It is found that besides fracture and nonunion, LIPUS also has clinical application prospect in treating osteoporosis, muscle injury, and motor nervous system diseases. |
| Key words: low-intensity pulsed ultrasound fracture nonunion osteoporosis muscle injury spinal cord injury motor neuron disease |
