| 摘要: |
| 子宫内膜异位症是指子宫内膜腺体及间质在宫腔外的部位种植或生长，其病理机制包括免疫炎性改变、氧化应激、上皮-间质转化及新生血管生成等。子宫内膜异位症好发于育龄期女性，严重影响患者的生殖健康和生活质量，目前主要通过手术及长期药物管理进行治疗。褪黑素是一种内源性吲哚胺类激素，通过作用于不同的信号转导通路发挥抗氧化、抗炎、调节免疫功能和促进细胞凋亡等多种生理功能，在癌症、心血管疾病、神经系统疾病等疾病的治疗中备受关注。近年来研究发现褪黑素可通过抑制雌激素合成、拮抗血管生成等作用抑制子宫内膜异位症的发展，并能有效缓解盆腔疼痛。本文就褪黑素在子宫内膜异位症中作用的研究进展进行综述，以期为子宫内膜异位症的药物治疗提供新的思路。 |
| 关键词: 子宫内膜异位症 褪黑素 氧化应激 血管生成 雌激素 |
| DOI：10.16781/j.CN31-2187/R.20230480 |
| 投稿时间：2023-08-25修订日期：2024-01-17 |
| 基金项目: |
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| Inhibitory effect of melatonin on endometriosis: research progress |
| SHOU Hejun,DUAN Hua* |
(Minimally Invasive Gynecology Center, Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University/Beijing Maternal and Child Health Care Hospital, Beijing 100006, China
* Corresponding author) |
| Abstract: |
| Endometriosis (EM) refers to the implantation or growth of endometrial glands and stroma outside the uterus. The pathological mechanism of EM includes immunoinflammatory changes, oxidative stress, epithelial-stromal transition and neovascularization. EM tends to occur in women of reproductive age and seriously affects the reproductive health and quality of life of patients. At present, it is mainly treated through surgery and long-term drug management. Melatonin is an endogenous indoleamine hormone, which has various physiological functions such as antioxidant, anti-inflammatory, immune regulation and apoptosis promotion through different signaling pathways. It has attracted much attention in the treatment of cancer, cardiovascular diseases and nervous system diseases. Recent studies have found that melatonin can also inhibit the development of EM by inhibiting estrogen synthesis and antagonizing angiogenesis, and can effectively relieve pelvic pain. This article reviews the research progress on melatonin in EM in order to provide new ideas for drug therapy of EM. |
| Key words: endometriosis melatonin oxidative stress angiogenesis estrogen |
