| 摘要: |
| 疼痛是子宫内膜异位症最常见和最严重的症状，目前尚无有效的治疗方法，且疼痛机制仍然不明。肥大细胞是一种可以与感觉神经相互作用、介导疼痛的免疫细胞，近年来研究发现肥大细胞在子宫内膜异位症疼痛发生中发挥重要作用。本文总结了肥大细胞通过炎症反应、血管生成、神经生长、外周和中枢神经敏化等途径参与子宫内膜异位症疼痛发生机制的最新进展，以期为子宫内膜异位症疼痛的机制研究和临床治疗开拓新思路。 |
| 关键词: 子宫内膜异位症 疼痛 肥大细胞 炎症 血管生成 神经生长 神经敏化 |
| DOI：10.16781/j.CN31-2187/R.20230315 |
| 投稿时间：2023-06-07修订日期：2023-11-09 |
| 基金项目:国家自然科学基金面上项目（82171636）. |
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| Role of mast cells in development of endometriosis pain: research progress |
| MAO Xinqi,ZHANG Xinmei* |
(Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China
* Corresponding author) |
| Abstract: |
| Pain is the most common and severe symptom of endometriosis. However, there is no effective treatment nowadays, and the mechanism of endometriosis pain remains poorly defined. Mast cells are immune cells that can interact with sensory nerves to induce endometriosis pain. Recent studies have shown that mast cells play a vital role in the development of endometriosis pain. This article summarizes the latest research to highlight advances in mast cells involving in endometriosis pain through inflammatory response, angiogenesis, nerve growth, and peripheral and central sensitization, hoping to provide new ideas for the mechanism research and clinical treatment of endometriosis pain. |
| Key words: endometriosis pain mast cells inflammation angiogenesis nerve growth neurosensitization |
