| 摘要: |
| 目的 评价亲属供肾者切除一侧肾脏后的长期安全性。方法 采用门诊、电话及微信等随访方式，对91例于2006－2011年在我院接受亲属供肾切除术的供者进行至少10年的随访。在随访期间，对供者的血肌酐、血尿酸、血尿素氮、估计的肾小球滤过率（eGFR）、血尿、尿蛋白、血压、血糖和血脂等指标进行检测，分析供者供肾切除手术前后上述指标的变化。结果 术后1个月，供者的血肌酐、血尿素氮、血尿酸水平均较术前升高（均P＜0.05），但均处于正常参考值范围内。继续随访至术后1、3、5、10年，与术后1个月相比，供者血肌酐、血尿素氮、血尿酸水平相对稳定（均P＞0.05）。不同年龄段供者的eGFR术后长期保持相对稳定。供者术后出现镜下血尿3例、蛋白尿4例，经过休息、对症治疗后均有所好转。10例（11.0%）供者术后发生高血压，5例（5.5%）发生高脂血症，5例（5.5%）发生糖尿病，无死亡患者。结论 对于健康的亲属供者，供肾切除手术安全、可行。但为确保亲属供者的安全，供肾切除术前的全面评估和术后的定期规律随访至关重要。 |
| 关键词: 活体亲属肾移植 肾供体 安全性 随访 |
| DOI：10.16781/j.CN31-2187/R.20240161 |
| 投稿时间：2024-03-11修订日期：2024-08-27 |
| 基金项目: |
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| Long-term donor safety analysis after related renal transplantation in a single center |
| WANG Jiyuan,CHEN Yu,YANG Jinghui,ZHENG Xueyang,DING Yue,HAN Shu* |
(Department of Organ Transplantation, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Objective To evaluate the long-term safety of related kidney donors after unilateral nephrectomy. Methods A total of 91 related donors who received nephrectomy in our hospital from 2006 to 2011 were followed up for at least 10 years by outpatient, telephone, or WeChat. During the follow-up period, the serum creatinine, serum uric acid, blood urea nitrogen, estimated glomerular filtration rate (eGFR), hematuria, urinary protein, blood pressure, blood glucose and blood lipids of the donors were detected, and the changes before and after nephrectomy were analyzed. Results At 1 month after operation, the levels of serum creatinine, blood urea nitrogen and serum uric acid of the donor were significantly higher than those before operation (all P＜0.05), but still within the normal range. The patients were followed up for 1, 3, 5 and 10 years after operation. Compared with 1 month after operation, the serum creatinine, blood urea nitrogen and serum uric acid were relatively stable (all P＞0.05). The eGFR of donors of different ages remained relatively stable for a long time after operation. There were 3 cases of endoscopic hematuria and 4 cases of proteinuria after surgery, and these symptoms were relieved after rest and symptomatic treatment. Ten (11.0%) donors developed hypertension 5 (5.5%) developed hyperlipidemia, and 5 (5.5%) developed diabetes mellitus. No patient died. Conclusion Nephrectomy is safe and feasible for healthy related donors. To ensure the safety of the donors, comprehensive evaluation before nephrectomy and regular follow-up after nephrectomy are essential. |
| Key words: living related renal transplantation kidney donors safety follow-up |
