| 摘要: |
| 目的 探讨中国中老年人肺功能、慢性肺疾病（CLD）与头痛之间的关联。方法 采用横断面研究，对2015年中国健康与养老追踪调查（CHARLS）项目中45岁及以上参与者的数据进行分析。头痛基于自我报告诊断，CLD及哮喘根据自我报告的医生诊断或健康评估和用药数据诊断。以呼气流量峰值（PEF）作为肺功能的指标。采用多因素logistic回归模型分析PEF、哮喘、CLD与头痛的相关性，并对PEF与头痛之间的关系进行限制性立方样条（RCS）分析和亚组分析。结果 共纳入12 661名中老年参与者，头痛的患病率为14.42%（1 826/12 661），其中男性患病率为9.07%（558/6 151），女性患病率为19.48%（1 268/6 510）。完全调整协变量后，PEF每增加1 L/s，头痛风险降低7%（OR＝0.93，95% CI 0.90～0.96，P＜0.001）。以PEF四分位数分组分析，随着PEF的增高，头痛风险呈下降趋势（Q2、Q3和Q4组的OR分别为0.92、0.82和0.72，P趋势＜0.001）。哮喘（OR＝1.78，95% CI 1.43～2.20，P＜0.001）和CLD（OR＝2.21，95% CI 1.92～2.53，P＜0.001）与头痛风险呈正相关。RCS分析显示，PEF与头痛风险之间存在线性负相关关系（P整体＜0.001，P非线性＝0.57）。亚组分析显示，高血压病史对PEF与头痛之间的负相关性有显著影响（P交互＜0.001）。结论 在中国中老年人中，肺功能指标PEF与头痛风险呈负相关，而哮喘和CLD与头痛风险呈正相关。关注并改善中老年人群的肺功能可能是预防或缓解头痛的有效策略。 |
| 关键词: 肺功能 呼气峰值流量 头痛 中老年人 慢性肺疾病 |
| DOI：10.16781/j.CN31-2187/R.20240369 |
| 投稿时间：2024-05-28修订日期：2024-09-20 |
| 基金项目:国家自然科学基金（82302421）. |
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| Correlations of pulmonary function and chronic lung diseases with headache in middle-aged and elderly people in China: based on CHARLS |
| GUO Yu,WANG Changli,DING Ren,LU Wenbin,LI Xiaofei* |
(Department of Anesthesiology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Objective To explore the relationships between headache and pulmonary function, chronic lung disease (CLD) in middle-aged and elderly people in China. Methods This cross-sectional study collected data from participants aged 45 and above in the 2015 China Health and Retirement Longitudinal Study (CHARLS). Headache was diagnosed based on self-report, and CLD and asthma were defined by self-reported doctor diagnoses or a combination of health assessments and medication use. Peak expiratory flow (PEF) was used as an indicator of pulmonary function. Multivariable logistic regression model was used to analyze the correlations between PEF, asthma, CLD, and headache. Relationship between PEF and headache was analyzed by restricted cubic spline (RCS) analysis and subgroup analysis. Results Among 12 661 middle-aged and elderly participants, the prevalence of headache was 14.42% (1 826/12 661), with a prevalence of 9.07% (558/ 6 151) in males and 19.48% (1 268/6 510) in females. After full adjustment for covariates, each 1 L/s increase in PEF was associated with a 7% reduction in the risk of headache (odds ratio ［OR］＝0.93, 95% confidence interval ［CI］ 0.90-0.96, P＜ 0.001). Categorizing PEF into quartiles (Q1-Q4), as the increase of PEF, the risk of headache significantly decreased (ORs for Q2, Q3, and Q4 were 0.92, 0.82, and 0.72, respectively, Ptrend＜0.001). Additionally, asthma (OR＝1.78, 95% CI 1.43-2.20, P＜0.001) and CLD (OR＝2.21, 95% CI 1.92-2.53, P＜0.001) were positively associated with the risk of headache. RCS analysis indicated a negative linear correlation between PEF and the risk of headache (Poverall＜0.001, Pnon-linear＝ 0.57). Subgroup analysis revealed that a history of hypertension had a significant impact on the negative association between PEF and headache (Pinteraction＜0.001). Conclusion There is a significant negative correlation between PEF and headache among middle-aged and elderly people in China, while asthma and CLD are positively associated with headache. Improving lung function in middle-aged and elderly populations may be an effective strategy for preventing or alleviating headache. |
| Key words: pulmonary function peak expiratory flow headache middle-aged and elderly people chronic lung diseases |
