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| 非编码RNA和蛋白质组学在辐射生物剂量学中的应用 |
| 刘星雨1,2,3,王涛3,左长京3,蔡建明1,2* |
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(1. 海军军医大学(第二军医大学)海军医学系, 上海 200433;
2. 温州医科大学公共卫生与管理学院, 温州 325035;
3. 海军军医大学(第二军医大学)第一附属医院核医学科, 上海 200433
*通信作者) |
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| 摘要: |
| 理想的辐射生物标志物应该能够快速、便捷、准确地评估机体所接受的辐射剂量，并能预测辐射损伤效应。基于基因或分子表达谱的辐射剂量评估是辐射生物剂量学领域的研究热点。非编码RNA和蛋白质组学具有高通量的特点，可以实现实时、快速检测，在辐射生物剂量学研究中展现出巨大潜力。本文总结了近年来非编码RNA和蛋白质作为潜在辐射生物标志物的研究进展，并对其影响因素、应用场景等进行综述。 |
| 关键词: 电离辐射 辐射生物剂量学 辐射生物标志物 非编码RNA 蛋白质组学 |
| DOI：10.16781/j.CN31-2187/R.20230108 |
| 投稿时间：2023-03-13修订日期：2024-05-10 |
| 基金项目:海军军医大学（第二军医大学）第一附属医院“十四五”学科固海计划（GH145-22）. |
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| Application of non-coding RNA and proteomics in radiation biodosimetry |
| LIU Xingyu1,2,3,WANG Tao3,ZUO Changjing3,CAI Jianming1,2* |
(1. Faculty of Naval Medicine, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. School of Public Health and Management, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China;
3. Department of Nuclear Medicine, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| An ideal ionizing radiation biomarker should be able to quickly, conveniently and accurately assess the radiation dose received by individuals, and can predict the effect of radiation-induced damage.Radiation dose assessment based on gene or molecular expression profiles is a research focus in the field of radiation biodosimetry.Non-coding RNA and proteomics have the characteristic of high-throughput that allows for rapid and real-time detection, making them highly potential for radiation biodosimetry research.This paper summarizes the research progress of non-coding RNA and proteins as potential radiation biomarkers in recent years, and also reviews their influencing factors and application scenarios. |
| Key words: ionizing radiation radiation biodosimetry radiation biomarkers non-coding RNA proteomics |
