| 摘要: |
| 肝细胞癌（HCC）是我国最常见恶性肿瘤之一，大部分患者在确诊时已处于中晚期，失去了根治性切除的机会。近年来，靶向、免疫及放射治疗在不可切除HCC中的作用日益凸显。尽管HCC对放射线敏感，但因肝脏对放射线的耐受性较低，放射治疗在临床上的地位常常被低估。随着放射治疗技术的发展，其在不可切除HCC中的应用日益广泛。无论是单纯放射治疗还是放射治疗联合其他治疗，均对不可切除HCC患者显示出明显的生存获益。本文重点阐述放射治疗及其与其他方法的联合治疗在不可切除HCC中的临床应用及最新研究进展。 |
| 关键词: 肝肿瘤 肝细胞癌 放射治疗 联合治疗 |
| DOI：10.16781/j.CN31-2187/R.20230004 |
| 投稿时间：2023-01-06修订日期：2023-06-25 |
| 基金项目:国家自然科学基金面上项目（82270634，81772529，81970453），上海市科学技术委员会科技创新行动计划（20XD1405100）. |
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| Radiotherapy for unresectable hepatocellular carcinoma: application and research progress |
| CHEN Wuyu,LIU Fuchen,FENG Xiaochen,LIU Hui* |
(Department of Hepatic Surgery (Ⅲ), The Third Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200438, China
*Corresponding author) |
| Abstract: |
| Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China.When HCC is diagnosed, most patients have been at the middle or advanced stage and have lost the chance of radical resection.In recent years, the roles of targeted therapy, immunotherapy, and radiotherapy have become increasingly prominent in the treatment of unresectable HCC.Although HCC is sensitive to radiation, the clinical value of radiotherapy is often underestimated due to the low tolerance of liver to radiation.With the development of radiotherapy technology, radiotherapy has been widely used in unresectable HCC.Patients can gain more survival benefits whether treated with radiotherapy alone or in combination with other treatments.This review focuses on the application and progress of radiotherapy and its combination therapy in unresectable HCC. |
| Key words: liver neoplasms hepatocellular carcinoma radiotherapy combination therapy |
