| 摘要: |
| 阿尔茨海默病是一种神经退行性疾病，其发病机制复杂，尚未完全阐明。近年来的研究表明，脂质代谢异常和炎症反应在阿尔茨海默病的发生和进展中发挥重要作用。本文从脂质代谢紊乱与炎症反应增加及阿尔茨海默病的关系、脂质介质的调节作用、小胶质细胞在这些过程中的作用等方面入手，阐述脂质代谢如何调节炎症反应，并进一步影响阿尔茨海默病的病理过程。 |
| 关键词: 脂质代谢 神经炎症 小胶质细胞 阿尔茨海默病 |
| DOI：10.16781/j.CN31-2187/R.20230595 |
| 投稿时间：2023-10-30修订日期：2024-12-26 |
| 基金项目:国家自然科学基金（32170878）. |
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| Lipid metabolism modulates inflammatory response in Alzheimer’s disease: research progress |
| ZHANG Yike,HAN Chaofeng* |
(Department of Histology and Embryology, College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Alzheimer’s disease is a neurodegenerative disorder characterized by complex and not fully understood pathogenesis. Recent research has revealed that abnormalities in lipid metabolism and inflammatory responses play a crucial role in the development and progression of Alzheimer’s disease. This review aims to explore the modulatory effects of lipid metabolism on inflammatory responses and their subsequent influence on the pathological processes of Alzheimer’s disease from the aspects of the relationship between dysregulated lipid metabolism, increased inflammatory responses, and Alzheimer’s disease, the regulatory effects of lipid mediators, and the role of microglia in these processes. |
| Key words: lipid metabolism neuroinflammation microglia Alzheimer’s disease |
