| 摘要: |
| 糖尿病已成为影响人类健康的重大慢性疾病，目前控制血糖的主要手段仍依赖于口服和注射各类降糖药物。近年来，干细胞疗法作为一种新兴治疗手段备受关注，其中间充质干细胞以其低免疫原性、免疫调节功能、多向分化潜能成为重点研究对象。目前间充质干细胞治疗糖尿病及其并发症的临床研究较为广泛，多项研究证明了治疗的有效性和安全性。间充质干细胞治疗糖尿病的可能机制包括归巢效应及改善β细胞功能、间充质干细胞的分化、胰岛的再生与存活、免疫调节功能、改善胰岛素抵抗等。基因改造、联合治疗、外泌体应用、封装技术等手段可能有助于改善间充质干细胞的治疗效果。目前干细胞治疗糖尿病仍存在许多风险和挑战，有待深入研究。 |
| 关键词: 间充质干细胞 糖尿病 并发症 β细胞 免疫调节 胰岛功能 |
| DOI：10.16781/j.CN31-2187/R.20240199 |
| 投稿时间：2024-03-28修订日期：2024-09-05 |
| 基金项目:海军军医大学第一附属医院“十四五”学科固海计划项目. |
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| Mesenchymal stem cells in the treatment of diabetes mellitus: research progress |
| JIN Kaimeng,LU Jin* |
(Department of Endocrinology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Diabetes mellitus is a serious chronic disease globally. However, the main methods for controlling blood glucose are still injections and oral hypoglycemic drugs. Stem cell therapy as a novel treatment is gaining attention, especially mesenchymal stem cells (MSCs), which are widely studied due to their low immunogenicity, immunomodulatory properties, and multi-lineage differentiation potential. Clinical research on MSC therapy for diabetes mellitus and its complications is extensive, with multiple studies demonstrating the effectiveness and safety of the treatment. The potential mechanisms of MSC therapy for diabetes mellitus include homing effects and improvement of β-cell function, differentiation of MSCs, regeneration and survival of islets, immune modulation, and improvement of insulin resistance. Possible methods to enhance the therapeutic effects of MSCs in the future could include genetic modification, combination therapies, application of exosomes, and encapsulation techniques. There are still many risks and challenges associated with stem cell therapy for diabetes mellitus that require further in-depth research. |
| Key words: mesenchymal stem cells diabetes mellitus complications β cells immune regulation islet function |
