| 摘要: |
| 目的 探讨食管癌放疗前后血清转化生长因子β1（TGFβ1）水平改变与放疗疗效及预后的关系。方法:采用ELISA方法检测56例明确诊断的食管癌患者放疗前后的血清TGF β1水平，并将其与病变范围、部位、X线病理分型、近期疗效及转移复发的关系进行对比分析。结果:放疗前食管癌患者血清TGF β1平均水平明显高于正常对照组（P<0.01），血清TGF β1的表达与病变部位、病变长度、X线病理分型无关(P>0.05)；放疗后血清TGF β1水平下降(P<0.05)，其改变与近期疗效及转移复发相关(P<0.01)。结论:血清TGF β1水平可作为监测食管癌近期放疗疗效和预后、提示后续或辅助治疗的一项参考指标。 |
| 关键词: 食管肿瘤 转化生长因子β1 放射疗法 |
| DOI： |
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| 基金项目: |
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| The clinic significance of the changes of serum transforming growth factor β1 before and after radiotherapy in esophageal carcinoma patients |
| 余友渔,兰莉,董昭,金冶宁,孙苏平 |
| () |
| Abstract: |
| Objective： To evaluate the relation between the changes of serum transforming growth factor beta1 (TGFβ1) and response to radiotherapy in esophageal carcinoma before and after radiotherapy. Methods: Fifty six newly diagnosed esophageal carcinoma patients were studied. Serum samples for TGFβ1 were obtained before and after radiotherapy. An enzyme-lined immunosorbent assay(ELISA) was used to measure changes of serum TGFβ1 levels and compared with the limits, location, X-ray pathologic, the immediate response to radiotherapy, metastasis and recurrence. Results: The data showed that the serum TGFβ1 level in esophageal carcinoma patients before radiotherapy was significantly higher than that of healthy controls（P<0.01）.The changes of serum levels after radiotherapy were also closely related to the limits, the immediate response to radiotherapy and metastasis and recurrence（P<0.01）, but were not related to the location, X-ray pathological pattern of the lesions. Conclusion: These results suggest that the serum TGFβ1 level may be a useful marker for monitoring the response and prognosis after radiotherapy in patients with esophageal carcinoma. |
| Key words: esophageal neoplasms transforming growth factor beta1 radiotherapy |
