| 摘要: |
| 目的:研究甘露醇与氟康唑合用对氟康唑药代动力学的影响.方法:采用HPLC法测定6条杂种犬的血药浓度,3P87药代动力学软件拟合药-时曲线。结果和结论:测得单用及合用时氟康唑的主要药代动力学参数ka 分别为(0.19±0.08)和(0.40±0.13)h-1(P<0.05),t1/2ka分别为(3.97± 1.21)和(2.05±1.08)h(P<0.05),而cmax和AUC两组无明显差异P>0.05) |
| 关键词: 氟康唑、甘露醇、药代动力学、色谱法，高效液相 |
| DOI： |
|
| 基金项目: |
|
| Influence of mannitol on the pharmacokinetics of fluconazole in dogs |
| 朱才娟,马玉杰,邵元福,魏淑香,钱方,姜国华 |
| () |
| Abstract: |
| Objective: To study the influence of mannitol on the pharmacokinetics of fluconazole. Methods:After oral administration the concentration of fluconazole in serum was determined by HPLC. The concentration of fluconazole in serum-time profiles were conformed by 3P87 program. Results and conclusion: The pharmacokinetic parameters of fluconazole alone and combined with mannitol were: ka=(0.19±0.08) and (0.40±0.13) h-1 (P<0.05), t1/2ka =( 3.97±1.21) and (2.05±1.08) h (P<0.05). No significant differences were noted between fluconazole alone and in combination with mannitol in cmax and AUC (P>0.05). |
| Key words: fluconazole monnitol pharmacokinetics HPLC |
