| 摘要: |
| 目的：探讨免疫抑制药物对成人型多囊肾病（APKD）的治疗作用及其作用机制。方法：回顾总结24例APKD患者肾移植并免疫抑制治疗［均为常规的环孢素A（CsA）、硫唑嘌呤（Aza）、泼尼松（Pred）三联方案］前后情况，对比观察的指标是腰部胀痛、肉眼血尿、高血压、多囊肾大小。结果：移植术后腰部胀痛症状改善最为明显; 术前频发肉眼血尿者为83.3％，术后减为12.5％，相差非常显著（P<0.01）;高血压在术后1个月内改善不明显，而在术后1年时改善非常明显（P<0.01）；多囊肾B超测定值，术前与术后各期相比, 大小无显著差异，呈现“稳定”状态。结论：APKD患者肾移植术后腰部胀痛、血尿、高血压等症状的改善可归因于免疫抑制药物的治疗作用。推测其作用机制，可能APKD属基因决定基础上的免疫性疾病，或免疫因素在其病程中起重要作用，因此免疫抑制药物可能对APKD具有治疗作用。 |
| 关键词: 多囊肾 免疫治疗 |
| DOI： |
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| 基金项目: |
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| Therapeutic effect of immunosuppressant for adult polycystic kidney disease |
| 齐隽,朱有华,闵志廉,王炜,王立明 |
| () |
| Abstract: |
| Objective: To discuss the therapeutic effect of immunosuppresant for adult polycystic kidney disease (APDK). Methods: Collecting 24 cases of APKD patients undergone the renal transplantation for 1-8 years (mean time is 3.18 years). The checking items were waist pain,haematuria,hypertension and polycystic kidney size before and after renal transplantation. Immunosuppressants include cyclosporine, azathioprine and prednisone. Results: After transplantation, release of waist pain was most obvious; occurrence rate of haematuria decreased from 83.3%to 12.5%(P<0.01); hypertention did not change in 1 month but improved in 1 year (P<0.01); polycystic kidney size examined by B-ultrasound showed no difference and stayed in “steady” state. Conclusion: Immunosuppressants contribute to all the above improvements. APKD may be gene-depended immunodisease or immunity plays an important role in its pathogenesis. So immunosuppressant may be therapeutically effective for APKD. |
| Key words: polycystic kidney immunotherapy |
