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  • 王琳△,贾宇△,姜远英*.脂筏参与耐药: 多药耐药相关ABC转运蛋白与脂筏的关系[J].第二军医大学学报,2011,32(2):213-215    [点击复制]
  • WANG Lin△,JIA Yu△,JIANG Yuan-ying*.Lipid raft involved in drug resistance:relationship between multidrug resistance ATP-binding cassette transporters and lipid raft[J].Acad J Sec Mil Med Univ,2011,32(2):213-215   [点击复制]
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脂筏参与耐药: 多药耐药相关ABC转运蛋白与脂筏的关系
王琳△,贾宇△,姜远英*
0
(第二军医大学药学院新药研究中心,上海 200433)
摘要:
\[摘要\]脂筏(lipid raft)和细胞的许多功能,如信号转导、蛋白质和脂类的转运等都相关。近来有研究发现,与多药耐药密切相关的ABC转运蛋白(ATP-binding cassette transporter)定位于脂筏中,因此推测脂筏可能与耐药性有一定关系。本文综述了3种和耐药相关的ABC转运蛋白的定位与其功能之间的联系,分别是和肿瘤细胞多药耐药相关的ABC转运蛋白Pgp/ABCB1、MRP1/ABCC1以及与白假丝酵母菌(白念珠菌)多药耐药相关的ABC转运蛋白Cdr1p;并进一步讨论了脂筏的重要组成成分胆固醇和鞘脂对上述3种ABC转运蛋白的定位和功能的影响。
关键词:  脂筏  多药耐药  白假丝酵母菌  ATP结合盒转运蛋白
DOI:10.3724/SP.J.1008.2011.0213
投稿时间:2010-06-07修订日期:2011-01-09
基金项目:国家杰出青年科学基金(30825041).
Lipid raft involved in drug resistance:relationship between multidrug resistance ATP-binding cassette transporters and lipid raft
WANG Lin△,JIA Yu△,JIANG Yuan-ying*
(Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China)
Abstract:
\[Abstract\]Lipid rafts have been implicated in many cellular functions, including protein and lipid transport and signal transduction. Recently ATP-binding cassette (ABC) transporters, which are associated with multidrug resistance, have been found in lipid rafts; therefore they might be related to drug resistance. Here we introduce the relationship between the localization and functions of three multi-drug related ABC transporters, including two relevant to multidrug resistance in tumor cells(Pgp/ABCB1 and MRP1/ABCC1) and one relevant to multidrug resistance in Candida albicans (Cdr1p). We also discuss the influence of sphingolipids and cholesterol, two major components of lipid rafts, on the localization and function of the above three ABC transporters.
Key words:  lipid raft  multidrug resistance  Candida albicans  ATP-binding cassette transporters