| 摘要: |
| 粒状头样2(GRHL2)基因是果蝇粒状头样基因在哺乳动物中的同源基因之一,参与年龄相关的听觉损伤修复、神经管闭合、上皮完整性和创伤修复等,也参与肿瘤的发生、发展。随着对GRHL2基因与肿瘤关系及其作用机制研究的深入,提示其在不同肿瘤中的作用机制不同。本文对GRHL2家族生物学功能及其在消化系统肿瘤中的研究进展进行综述,为GRHL2的深入研究提供背景。 |
| 关键词: 粒状头样2 消化系统肿瘤 肝肿瘤 胃肿瘤 结直肠肿瘤 |
| DOI：10.3724/SP.J.1008.2015.1233 |
| 投稿时间：2015-03-21修订日期：2015-08-21 |
| 基金项目:第二军医大学长海医院"1255"联合攻关项目子课题(CH125510304). |
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| Relationship between GRHL2 gene and tumor of the digestive system: research progress |
| GAO Yi-sha,TA Na,ZHENG Jian-ming* |
(Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Grainyhead-like 2 (GRHL2), an mammalian homolog of Drosophila grainyhead, is associated with age-related hearing impairment repair, neural tube closure, epidermal integrity, and wound healing; it also takes part in the initiation and progression of cancer. As the research going on, GRHL2 has been proven to be of great importance in different molecular mechanisms of different types of cancer. We herein reviewed the biological functions of GRHL2 family and the roles of GRHL2 proteins in digestive system neoplasms, hoping to lay a foundation for more advanced research of GRHL2. |
| Key words: graniyhead-like 2 digestive system neoplasm liver neoplasm stomach neoplasm colorectal neoplasm |
