| 摘要: |
| 目的:探讨老年女性2型糖尿病患者高血压与骨质疏松（osteoporosis, OP）、骨密度（bone mineral density, BMD）的关系。方法:将179例老年女性T2DM患者分为2组，高血压组124例，非高血压组55例。测量腰椎和髋部的BMD。χ2检验比较2组总OP、腰椎OP、髋部OP的患病率，协方差分析各部位BMD的差别，并用二元logistic逐步回归方法分析OP与相关危险因素之间的相关性。 结果:非高血压组总OP、腰椎OP、髋部OP的患病率均高于高血压组（P值分别为P总=0.037、P腰=0.042、P髋=0.051）。2组BMD比较，高血压组各部位的BMD均高于非高血压组，其中L3、L4 BMD差异有统计学意义（P值分别为P3=0.040，P4=0.021）。但在校正体质量指数（body mass index, BMI）后P值均明显增大，2组BMD均无统计学差异，在校正C肽后P值也变大，但无校正BMI后P值变化明显。应用二元Logistic回归方法进行分析，年龄、BMI、骨钙素与OP有关，而高血压与OP无明显的相关。结论:OP与年龄、BMI、骨钙素有关，而高血压与OP之间没有必然的联系。 |
| 关键词: 2型糖尿病 骨质疏松 体质量指数 高血压 老年人 女性 |
| DOI：10.3724/SP.J.1008.2009.0424 |
| 投稿时间：2008-09-05修订日期：2009-03-03 |
| 基金项目: |
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| Relationship between hypertension and osteoporosis in elderly female with type 2 diabetes mellitus |
| ZHANG Xiu-zhen, WANG Bo*, XUAN Miao, YANG Jun, SONG Li-ge |
| (Department of Endocrinology, Tongji Hospital, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Objective:To investigate the relationship of hypertension with osteoporosis（OP）and bone mineral density(BMD) in elderly type 2 diabetic women. Methods: A total of 179 elderly type 2 diabetic women were categorized into hypertension group（n=124）and nonhypertension group（n=55）. Lumbar and hip BMD were measured by dualenergy Xray absorptiometry. Prevalences of osteoporosis were compared between the two groups using Chisquare test, and BMD was compared using covariance analysis. The correlation between the osteoporosis and risk factors was analyzed using binary logistic regression method. Results: The prevalences of osteoporosis（total OP, lumber OP and hip OP） in nonhypertension group were higher than that of the hypertension group(Pt=0.037, Pl=0.042 and Ph=0.051, respectively). Lumbar and hip BMD in the hypertension group was higher than that in the nonhypertension group, and there were significant differences in L3 and L4 BMDs between the two groups (P3=0.040，P4=0.021); however, the difference disappeared after adjustment for body mass index (BMD). After adjustment for C peptide, the P value also increased, but not as obvious as after adjustment for BMI. Binary logistic regression analysis showed that OP was associated with age, BMI and osteocalcin, but not with hypertension. Conclusion: OP is associated with the age, BMI, and osteocalcin, but not with hypertension in elderly type 2 diabetic women. |
| Key words: type 2 diabetes mellitus osteoporosis body mass index hypertension aged female |
