| 摘要: |
| 目的探讨细胞外基质金属蛋白酶诱导因子(EMMPRIN)、细胞外基质金属蛋白酶(MMP)-7表达与子宫内膜癌侵袭转移的关系。 方法收集对照组(包括11例增生期子宫内膜,11例分泌期子宫内膜,11例单纯性增生子宫内膜,11例复杂性增生子宫内膜)、不典型增生组(51例)和子宫内膜癌组(82例)子宫内膜标本, 应用免疫组化法测定标本中 EMMPRIN和MMP-7的表达,采用SAS 6.12软件比较EMMPRIN和MMP-7阳性表达率在3组间的差异,并分析EMMPRIN和MMP-7蛋白表达与子宫内膜癌临床病理特征的关系。结果对照组、不典型增生组、子宫内膜癌组EMMPRIN和MMP-7的阳性表达率分别为9.09%(4/44)和6.82%(3/44)、43.13%(22/51)和41.17%(21/51)、59.76%(49/82)和61.00%(50/82),组间差异有统计学意义(P<0.05)。不同年龄、不同原发肿瘤大小的子宫内膜癌患者间EMMPRIN、MMP-7的表达差异无统计学意义,但不同组织学分级、淋巴结转移与否患者间EMMPRIN、MMP-7的表达差异有统计学意义(P<0.05)。Spearman等级相关性检验分析表明子宫内膜癌组织中EMMPRIN的表达和MMP-7的表达正相关(r=0.863,P<0.01)。结论EMMPRIN和MMP-7与子宫内膜癌的发生、发展及侵袭转移有关,可能协同促进了子宫内膜癌的淋巴结转移。 |
| 关键词: 细胞外基质金属蛋白酶诱导因子 基质金属蛋白酶7 子宫内膜肿瘤 肿瘤转移 肿瘤侵润 |
| DOI：10.3724/SP.J.1008.2011.0563 |
| 投稿时间：2011-03-01修订日期：2011-04-15 |
| 基金项目: |
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| Association of EMMPRIN and MMP-7 protein expression with endometrial cancer invasion and metastasis |
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| Abstract: |
| Objective：To analyze the expressions of EMMPRIN and MMP-7 in human endometrial cancer,and to evaluate the clinical significance of these two markers in the progression of endometrial cancer．Methods: The expressions of EMMPRIN and MMP-7 was examined by immunohistochemistry in all specimens,and the results were statistically analyzed．Results：The positive rates of EMMPRIN and MMP-7 in normal endometrium 、atypical hyperplasia and endometrial carcinoma were 9.09％ and 6.82％（4/44 and 3/44）、43.1% and 41.2%（22/51and 21/51）、61％ and 59.8％（50/82 and 49/82）,respectively,with significant differences found between the latter two groups(P<0.05). EMMPRIN and MMP-7 expressions in endometrial cancer was not correlated with the size of primary tumor or patient ages，ang it was correlated with histological grades and lymphatic metastasis(P<0.05). Spearman rank correlation test analysis showed that the expressions of EMMPRIN and MMP-7 in endometrial cancer was positively correlated with them (r = 0.863, P <0.01). Conclusion：EMMPRIN and MMP-7 may participate in the development ,progression,metastasis of endometrial cancer, may be synergistic in endometrial cancer of the lymph node metastases． |
| Key words: EMMPRIN MMMP-7 endometrial cancer immunohistochemistry |
